Quinidine, Hepatotoxicity

Quinidine-induced Syncope.

Since quinidine was introduced by Frey in 1918 it has remained the drug of choice for the conversion of certain arrhythmias to sinus rhythm and for the maintenance of normal rhythm once achieved. It is commonly used in this manner for atrial fibrillation, atrial flutter, -paroxysmal tachycardia of atrial, nodal, and ventricular origin, and ventriculat fibrillation. It has also been employed as ...

Quinidine-induced reversible pneumonitis.

We report a patient who developed fever and rapidly progressing lung infiltrates 4 days after the beginning of continuous quinidine sulfate therapy. The fever disappeared during the following 48 h and the pneumonitis slowly resolved over the next month once quinidine therapy was stopped. The diagnosis of quinidine-induced pneumonitis, which has not previously been reported in the literature (to...

Antiarrhythmic Therapy: Quinidine Gluconate

3. Sicart M, Besse P, Choussat A, Bricaud H: Action hemodynamique de l'amiodarone intra-veineuse chez l'homme. Arch Mal Coeur 3: 219, 1977 4. Charlier R, Delaunois G, Bauthier J: Caracteristiques et mecanismes de l'action de l'aamiodarone sur le debit cardiaque. Arzneimihel-Forschung 22: 1968, 1972 5. Charlier R, Delaunois G, Bauthier J: Incidence de l'amiodarone et de quelques beta-bloquants s...

Control of quinidine dosage.

The usefulness of quinidine in treatment of cardiac arrhythmias is often limited by the difficulty of determining adequate dosage. When control has not been effected by small doses, the physician may be deterred from increasing these because of the risk of toxicity. The electrocardiogram does not help to indicate that this may be imminent, since the effects of overdosage (widening of QRS and ve...

Quinidine. Worse than adverse?